Surname Rubio Santana (Rubio Santana 
) , all around the world, is a very rare family name. The surname Rubio Santana is habitual in Spain, where it is a very rare surname, and Ecuador. Very seldom, Rubio Santana is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Rubio Santana | Mexico, Spain, Ecuador |
Mario, Oscar, Andres, and Felipe Ramon